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• Elevated circulatory levels of leptin and resistin impair therapeutic efficacy of dacarbazine in melanoma under obese state18
• Epithelial to mesenchymal transition (EMT) is associated with attenuation of succinate dehydrogenase (SDH) in breast cancer through reduced expression of SDHC14
• Metabolomics of oncogene-specific metabolic reprogramming during breast cancer11
• SGLT2 inhibition slows tumor growth in mice by reversing hyperinsulinemia10
• Metabolic characterization of isocitrate dehydrogenase (IDH) mutant and IDH wildtype gliomaspheres uncovers cell type-specific vulnerabilities10
• Beta-hydroxybutyrate (3-OHB) can influence the energetic phenotype of breast cancer cells, but does not impact their proliferation and the response to chemotherapy or radiation9
• Cysteine catabolism and the serine biosynthesis pathway support pyruvate production during pyruvate kinase knockdown in pancreatic cancer cells8
• Stratification of cancer and diabetes based on circulating levels of formate and glucose7
• Protein interaction and functional data indicate MTHFD2 involvement in RNA processing and translation6
• CHCHD4 confers metabolic vulnerabilities to tumour cells through its control of the mitochondrial respiratory chain6